Important reasons for skin aging are a decreased number of fibroblasts and decreased synthesis of extracellular proteins in the dermis, as well as increased degradation of the collagenous matrix from UV radiation and other environmental stresses. This study investigated the effect of fulvic acid on fibroblasts and matrix metalloproteinases (MMPs) which are responsible for the degradation of collagen. There was a statistically significant inhibition of collagen degradation in the presence of fulvic acid at differing concentrations, highlighting fulvic acid’s anti-aging effect.
- Kinoshita, H, Kinoshita, M, Takahashi, A, Yuasa, S and Fukuda, K, 2012, Effect of fulvic acid on the ultraviolet induced skin aging: The effect of fulvic acid on fibroblasts and matrix metalloproteinase, Nishinihon Journal of Dermatology, 74, 4, 427-431
